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KMID : 0191120040190010079
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Journal of Korean Medical Science
2004 Volume.19 No. 1 p.79 ~ p.82
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The Outcomes of Hypertransfusion in Major ABO Incompatible Allogeneic Stem Cell Transplantation
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Park SH
Lee MH/Lee SH/Lee KE/Park J/Park JO/Kim K/Kim WS/Jung CW/Im YH/Kang WK/Park K/Kim SW/Lee KH/Lee JH
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Abstract
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Major ABO incompatibility may be potentially associated with immediate or delayed hemolysis and delayed onset of erythropoiesis in patients receiving allogeneic he-matopoietic stem cell transplantation (HSCT). To determine if hemolysis can be pre-vented by the inhibition of graft erythropoiesis, we performed hypertransfusion and assessed red cell transfusion requirement and independence. Between October 1995 and December 2001, 28 consecutive patients receiving major ABO incompatible HSCT at Samsung Medical Center were hypertransfused to maintain their hemoglobin levels at 15 g/dL or more. We retrospectively compared the outcomes of these patients with those of 47 patients at Asan Medical Center whose target hemoglobin levels were 10 g/dL. Reticulocyte engraftment was significantly delayed in hypertransfused group (51 days vs. 23 days; p= .001). There was no significant difference in the total amount of red cells transfused within 90 days post-HSCT (25 units vs. 26 units; p= .631). No significant difference in the time to red cell transfusion independence was observed between the two groups (63 days vs. 56 days; p=.165). In conclusion, we failed to improve red cell transfusion requirement and independence in major ABO incompatible HSCT with hypertransfusion.
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KEYWORD
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